World’s Larget Database for Cancer Drug Discovery Goes 3D

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Scientists have revolutionised the world’s largest database for cancer drug discovery by adding 3D structures of faulty proteins and maps of cancer’s communication networks, paving the way for more effective treatments.

The new version of canSAR database uses artificial intelligence to identify nooks and crannies on the surface of faulty cancer-causing molecules, as a key step in designing new drugs to block them. The database has already collated billions of experimental measurements mapping the actions of one million drugs and chemicals on human proteins, and has combined these data with genetic information and results from clinical trials, researchers said.

It allows scientists to identify communication lines that can be intercepted within tumour cells, opening up potential new approaches for cancer treatment. The growing database now holds the 3D structures of almost three million cavities on the surface of nearly 110,000 molecules.

“Our database is constantly growing with information and is the largest of its kind – with more than 140,000 users from over 175 countries,” said Bissan Al-Lazikani, from The Institute of Cancer Research in London, who led the team that developed canSAR.

“And we regularly develop new artificial intelligence technologies that help scientists make predictions and design experiments. Our aim is that cancer scientists will be armed with the data they need to carry out life-saving research into the most exciting drugs of the future. Scientists need to find all the information there is about a faulty gene or protein to understand whether a new drug might work,” Al-Lazikani said.

source : food.ndtv.com/health/worlds-largest-database-for-cancer-drug-discovery-goes-3d-1261965

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